She has also guest starred on IFC's Portlandia and Comedy Bang! , as well as numerous shows on Adult Swim, including The Heart, She Holler opposite Patton Oswalt and Metalocalypse.
Tamblyn launched her film career playing bit parts in her father's movies: Rebellious and Johnny Mysto: Boy Wizard. Her first major film role was in 2005's The Sisterhood of the Traveling Pants as Tibby Rollins, co-starring Alexis Bledel, America Ferrera, and Blake Lively.
In 2007, she co-founded Write Now Poetry Society, dedicated to creating unique and quality poetry programming.The non-profit has a long history with The Getty Museum, curating poetry events in conjunction with art openings, such as 2011's Dark Blushing, featuring new poems commissioned by poets Patricia Smith and NEA fellow Jeffrey Mc Daniel, based on works of art by Dante Gabriel Rossetti and William Blake.In a 2016 interview, Cross revealed that Tamblyn was a "staunch Hillary Clinton supporter" for the presidency of the United States and that it caused a "minor rift" in their marriage as he held a strong admiration for Senator Bernie Sanders.She is sometimes said to be the goddaughter of actors Dean Stockwell, musician Neil Young, and the late Dennis Hopper, although in a 2009 interview with Parade, Tamblyn explained that "godfather" was "just a loose term" for Stockwell, Hopper and Young, three famous friends of her father's, who were always around the house when she was growing up, and who were big influences on her life.Tamblyn attended a grade school for the theatrical arts from the age of 5 to Photos Cutest Celeb Kids on Instagram. I send my best wishes to you for a lifetime of amazing accomplishments and adventures, full of love, learning, and friendship.
She first came to national attention in her role on the soap opera General Hospital as Emily Quartermaine, followed by a starring role on the prime-time series Joan of Arcadia, portraying the title character, Joan Girardi for which she received Primetime Emmy and Golden Globe nominations.
She was discovered as an actress at the age of 9 when she starred in Pippi Longstocking.
In 2014 Tamblyn originated the role of Daisy Domergue for the live reading at the Ace Theater in Los Angeles of Quentin Tarantino's The Hateful Eight.
The School Library Journals review states that, "Free Stallion is a compilation of poetry that amounts to a portrait of the artist as a teenager....
Many of the selections are appropriately self-absorbed but move beyond journalistic catharsis to real insight and stunning language for one so young." Her poem "Bridgette Anderson" was one of the poems featured in Saul Williams' book Chorus, published by MTV Books in September 2011.
In 2007, Tamblyn starred in the CBS pilot Babylon Fields, an apocalyptic comedic drama about the undead trying to resume their former lives. In the same year, Tamblyn had a recurring role alongside her eventual husband David Cross in the IFC sitcom The Increasingly Poor Decisions of Todd Margaret.