She has said of her upbringing, "I lived in a tepee in Northern California and a van in Big Sur.With my dad, I lived in a beautiful house with a swimming pool and a tennis court and went to Europe for the summers.
Gugino has also had lead roles in the television series Political Animals (2012), Wayward Pines (2015), and Roadies (2016).
after which she travelled between her father and half-brother Carl Jr.'s home in Sarasota, and her Paradise, California, home, to which her mother moved her when she was four.
In 2009, Gugino was honored by the National Italian American Foundation (NIAF).
During the Foundation's 34th Anniversary Gala in Washington, D.
She also guest starred on the fourth season of Californication as Abby Rhodes, Hank Moody's attorney and love interest.
In mid-2012, Gugino had a lead role as Susan Berg, a Washington, D.
She starred in two short-lived TV series: ABC's Elmore Leonard crime drama Karen Sisco in 2003, and CBS' science fiction series Threshold in 2005.
That same year, Gugino appeared as Lucille in the feature film adaptation of Frank Miller's graphic novel, Sin City.
C., investigative reporter, on the USA Network's miniseries Political Animals.
In 2015, Gugino had a lead role in the disaster film, San Andreas, where she once again starred opposite Dwayne Johnson.
She is listed on Free Ones since 2001 and is currently ranked 1423th place.