On February 22, 2009, Seyfried presented an award and performed at the 81st Academy Awards ceremony.
In early March 2009 director Zack Snyder had tapped Seyfried to portray the lead role, Baby Doll, in Sucker Punch, Kirk Honeycutt of The Hollywood Reporter said, "Seyfried gives the character and her relationship all she's got, but she can't do all the heavy lifting.
Her subsequent supporting roles were in independent films, such as the drama Nine Lives (2005) and the crime drama Alpha Dog (2006).
She starred in the dramas Fathers and Daughters (2016) and First Reformed (2017), the crime comedy Gringo (2018), and the comedy-drama The Art of Racing in the Rain (2019).During Seyfried's time modeling, she appeared in the printed ads for clothing companies including Limited Too with Leighton Meester, and was featured on three covers of the Sweet Valley High novel series.(2008) and reprised her role in the sequel, Mamma Mia! Seyfried had lead roles in the black comedy horror Jennifer's Body (2009), the erotic thriller Chloe (2009), the romantic war drama Dear John (2010), and the romantic drama Letters to Juliet (2010).She starred in the dark fantasy historical romance Red Riding Hood (2011), the dystopian science fiction thriller In Time (2011), the thriller Gone (2012), the musical drama Les Misérables (2012), the biographical drama Lovelace (2013), and in the Seth Mac Farlane comedies A Million Ways to Die in the West (2014) and Ted 2 (2015).In December 2009, HBO confirmed that Seyfried would return for the show's fourth season, but that it would be her last, as Seyfried wished to concentrate on her film career and upcoming projects.
Following Big Love Seyfried had a supporting role, as Zoe, in the 2008 horror drama film Solstice, and co-starred alongside Meryl Streep in Mamma Mia! The film was the fifth highest-grossing film of 2008, The same year she was cast in the comedy-drama independent film Boogie Woogie.While she was initially considered to play the lead role of Cady Heron, played by Lindsay Lohan, the producers of the film decided that Seyfried should play Karen Smith, Regina's dim-witted "Plastic" friend and sidekick.Seyfried's performance in the film earned her, along with Lohan, Lacey Chabert, and Mc Adams, an MTV Movie Award in the category of "Best On-Screen Team".She played Joni Stafford on the ABC soap All My Children from 2002 to 2003.In 2003, Seyfried auditioned to play the role of Regina George in Mean Girls; the role eventually went to Rachel Mc Adams.Also in 2011, Seyfried became a spokesperson and model for Cle de Peau Beaute, a Japanese line of beauty products.